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The UK must "seize the opportunities" from Brexit while tackling deep-seated economic challenges "head on", Philip Hammond is to say in his second Budget.
The chancellor will promise investment to make Britain "fit for the future" as an "outward looking, free-trading nation" once it leaves the EU in 2019.
But he will also commit to supporting hard-pressed families with the cost of living and address housing shortages.
Labour say he should call time on austerity and boost public services.
In his Commons speech, which will begin at about 12:30 GMT, Mr Hammond will set out proposed tax and spending changes.
He will also update MPs on the current state of the economy, future growth projections and the health of the public finances.
He has been under pressure in recent months from sections of his party who argue that he is too pessimistic about the UK's prospects when it leaves the EU.
In response, he will set out his vision for the UK after Brexit as a "prosperous and inclusive economy" which harnesses the power of technological change and innovation to be a "force for good in the world".
Unlike past years, few announcements have been briefed out in advance of the big day.
But the chancellor is expected to announce more money for teacher training in England and extra cash to boost the numbers of students taking maths after the age of 16.
He has signalled he wants to speed up permitted housing developments and give more help to small builders.
In a nod to younger voters, discounted rail cards will be extended.
An extra £2.3bn for research and development and £1.7bn for transport links are designed to address the UK's lagging productivity.
Extra money is also expected to be found for new charge points for electric cars and for the next generation of 5G mobile networks.
Expect the theme of innovation to ring through the speech, with Mr Hammond hailing the UK as being "at the forefront of a technological revolution".
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